GO:0007249 biological_process I-kappaB kinase/NF-kappaB signaling
| PAG Title | GO:0007249 biological_process I-kappaB kinase/NF-kappaB signaling |
| PAG ID | TAX016864 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. |
| Species | Homo sapiens |
| nCoCo Score | 3,531 |
| Base PAG ID | TAX016864 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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